Schematic comparison of BRAIN BREW with an average sugary coffee beverage, which has 32mg caffeine and 9g of sugar per 100ml. Insights from various studies are summarized. The quintessence is that the rapid drop in blood sugar levels in a sugary coffee beverage after about an hour no subjective effect of caffeine is more noticeable, in contrast to BRAIN BREW. There are a multitude of differences, which will be explained in more detail below.
Assumptions: Average human caffeine half-life 4 hours (non-smoker); Blood sugar level in case of sobriety with 80 mg / dl; Rule of thumb: 10g of sugar increase the blood sugar level by 30-40mg / dl, here 35mg / dl; no other nutrient intake.
Breakdown of the different effect levels of caffeine
Chemical basis in connection with the receptor effect
To understand the effect of caffeine in the body, you have to start with the basics. The molecular formula for caffeine is C8H10N4O2. More importantly, however, the spatial structure of the 1,3,7-trimethyl-2,6 (1H, 3H) -puridine ion and 1,3,7-trimethylxanthine, respectively. It is a purine, belonging to the group of uric acid. The reason for the physiological effect is the concrete spatial structure. This is similar to the body’s own adenosine (C10H13N5O4), which determines the energy metabolism. Now the importance of the role of caffeine as a competitive antagonist of adenosine becomes clear. A particularly important purine is adenosine triphosphate (ATP). On the one hand, this provides energy, but on the other hand, regulation of it by the formation of adenosine in the dephosphorylation takes place. The adenosine level is thus directly related to physical and mental effort. This is also an explanation of why some people feel tired after morning exercise. BRAIN BREW can reduce this effect. It creates a negative feedback. The docking of adenosine at the receptors inhibits the release of norepinephrine, dopamine and acetylcholine.
Benuzodiazepines (sedatives) and alcohol also work on these receptors. Therefore, subjectively, we no longer feel the depressing effect of alcohol and feel better.
In order to avoid a developing tolerance due to the increasing number of receptors, the maximum consumption of two doses of BRAIN BREW per day should not be exceeded. This guarantees a long-term equal effect of BRAIN BREW.
Heart: heartbeat and capillary effects
Cardiac adenosine receptors are also responsible for the timed course of the heartbeat, so inhibition of this could in theory lead to cardiac arrhythmias. Recent studies, however, provided a counterintuitive result. These showed that daily consumption of e.g. four cups of coffee can reduce the incidence of cardiac arrhythmias by 18%. Also, protection against hypertension could be detected in coffee consumers.
Caffeine also causes capillaries in the body to expand and increase blood flow, while capillaries in the brain are narrowed, which can reduce headaches.
The stimulant caffeine also stimulates the energy metabolism. With a caffeine consumption of 400mg per day, the energy consumption increases by 107 kcal, which corresponds to about 5.6% of the basic daily energy conversion. This effect is reinforced by physical activity, as the fat burning and the degradation of fat is increased and thus less fat can be stored in the depots. Energy drinks do not have this effect because sugar counteracts this. Due to this fact and the BCAA BRAIN BREW is the ideal companion before the sport.
Lungs: oxygenation and functions
Caffeine leads to bronchial dilatation, the enlargement of the respiratory tract. The movements of the ciliated epithelium are also strengthened, which leads to better cleaning of the respiratory tract. The result is a better supply of oxygen to the body, which is conducive to physical and mental exertion.
Kidneys: Vitamin / mineral metabolism and fluid balance
To identify the effects on vitamin and mineral metabolism, it is necessary to isolate the part of the kidneys that has these tasks, the proximal tubule. Here it can be seen that the level of most B-group vitamins is reduced. It is noticeable here that a low level does not change much, whereas a higher level is more reduced. However, this effect is counteracted by the vitamins, antioxidants and minerals contained in coffee
Caffeine only affects the speed of kidney function, more specifically, it speeds up fluid processing, but it does not significantly affect the amount of fluid.
Liver: blood sugar
In the liver, caffeine is metabolized using the enzyme cytochrome P450. The enzyme CYP1A2 cleaves the original trimethylxanthine into dimethylxanthines and monomethylxanthines. Which in turn have different effects. The breakdown product theobromine, for example, in turn inhibits the breakdown of caffeine itself.
Gastrointestinal: absorption and effects
The absorption time of caffeine is 20min. In the blood circulation it arrived after 30-45min. Soft drinks and tea cause a slower intake of caffeine (more on that later in the text). Once in the blood, caffeine can easily cross the blood-brain barrier, which explains its rapid psychoactive effects. The maximum concentration is reached after about 1-1.5 hours. The effect varies from person to person. At 100kg body weight and a caffeine amount of 100mg, have 1kg body mass 1mg caffeine. At 50kg body weight and a caffeine amount of 100mg, have 1kg body mass 2mg caffeine. Thus, logically different effects arise for different physiological conditions. Furthermore, 68% of coffee drinkers report heartburn after consumption. BRAIN BREW has 70% less acid, which makes this coffee much more compatible and thus counteracts this problem.
Muscles: Power and Contraction
Strength and contract time Endurance and muscle strength are strengthened in two ways. On the one hand, the sodium-potassium pump is activated and, on the other, serotonin is increased. The neuromuscular coordination is also improved. All in all, it is thus possible to respond more quickly to mental demands, for example to unexpected traffic situations.
Differences in activity due to phytochemicals
The biosynthesis of caffeine is different to that in tea or cocoa. This difference leads to significant differences in effect between the various caffeine-containing foods. Even with the same caffeine value can be felt in the one effect, whereas in the other nothing changes. To explain this effect, one has to differentiate two compounds. First, caffeine binding to polyphenols (phytochemicals), such as guarana and tea, is the case. Another substance to be named here is L-Theanine. This has a caffeine opposite effect, so that the invigorating effect of caffeine may even be lost completely. Second, the binding of caffeine to chlorogenic acid, since regular roasting burns most phytochemicals. The binding to this acid leads to a direct release of action. Based on these findings, the unique effect of BRAIN BREW can now be better understood. Due to the longer brewing time of the coldbrew extraction method, a maximum of caffeine is dissolved out. In addition, the beans used are brighter and gentler roasted than average coffee and thus more substances are preserved. Consequently, both said compounds are present, which on the one hand leads to a partly direct effect, on the other hand to a longer-lasting effect (without the attenuation by L-theanine). BRAIN BREW is thus faster, longer lasting and stronger than teas and seeds. The effect of energy drinks has already been shown in various magazines and shown schematically in the graph above, resulting in a less healthy (sugar, chemicals) and short-lasting effect (1 hour). BRAIN BREW customers report effects of between 5 and 8 hours with unique clarity and alertness, with no guilty conscience.
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