BRAIN BREW vs. Sugary coffee beverage

Schematic comparison of BRAIN BREW with an average sugary coffee beverage, which has 32mg caffeine and 9g of sugar per 100ml. Insights from various studies are summarized. The quintessence is that the rapid drop in blood sugar levels in a sugary coffee beverage after about an hour no subjective effect of caffeine is more noticeable, in contrast to BRAIN BREW. There are a multitude of differences, which will be explained in more detail below.

Assumptions: Average human caffeine half-life 4 hours (non-smoker); Blood sugar level in case of sobriety with 80 mg / dl; Rule of thumb: 10g of sugar increase the blood sugar level by 30-40mg / dl, here 35mg / dl; no other nutrient intake.

Breakdown of the different effect levels of caffeine

Chemical basis in connection with the receptor effect

To understand the effect of caffeine in the body, you have to start with the basics. The molecular formula for caffeine is C8H10N4O2. More importantly, however, the spatial structure of the 1,3,7-trimethyl-2,6 (1H, 3H) -puridine ion and 1,3,7-trimethylxanthine, respectively. It is a purine, belonging to the group of uric acid. The reason for the physiological effect is the concrete spatial structure. This is similar to the body’s own adenosine (C10H13N5O4), which determines the energy metabolism. Now the importance of the role of caffeine as a competitive antagonist of adenosine becomes clear. A particularly important purine is adenosine triphosphate (ATP). On the one hand, this provides energy, but on the other hand, regulation of it by the formation of adenosine in the dephosphorylation takes place. The adenosine level is thus directly related to physical and mental effort. This is also an explanation of why some people feel tired after morning exercise. BRAIN BREW can reduce this effect. It creates a negative feedback. The docking of adenosine at the receptors inhibits the release of norepinephrine, dopamine and acetylcholine.

Benuzodiazepines (sedatives) and alcohol also work on these receptors. Therefore, subjectively, we no longer feel the depressing effect of alcohol and feel better.

In order to avoid a developing tolerance due to the increasing number of receptors, the maximum consumption of two doses of BRAIN BREW per day should not be exceeded. This guarantees a long-term equal effect of BRAIN BREW.

Heart: heartbeat and capillary effects

Cardiac adenosine receptors are also responsible for the timed course of the heartbeat, so inhibition of this could in theory lead to cardiac arrhythmias. Recent studies, however, provided a counterintuitive result. These showed that daily consumption of e.g. four cups of coffee can reduce the incidence of cardiac arrhythmias by 18%. Also, protection against hypertension could be detected in coffee consumers.

Caffeine also causes capillaries in the body to expand and increase blood flow, while capillaries in the brain are narrowed, which can reduce headaches.

Energy budget

The stimulant caffeine also stimulates the energy metabolism. With a caffeine consumption of 400mg per day, the energy consumption increases by 107 kcal, which corresponds to about 5.6% of the basic daily energy conversion. This effect is reinforced by physical activity, as the fat burning and the degradation of fat is increased and thus less fat can be stored in the depots. Energy drinks do not have this effect because sugar counteracts this. Due to this fact and the BCAA BRAIN BREW is the ideal companion before the sport.

Lungs: oxygenation and functions

Caffeine leads to bronchial dilatation, the enlargement of the respiratory tract. The movements of the ciliated epithelium are also strengthened, which leads to better cleaning of the respiratory tract. The result is a better supply of oxygen to the body, which is conducive to physical and mental exertion.

Kidneys: Vitamin / mineral metabolism and fluid balance

To identify the effects on vitamin and mineral metabolism, it is necessary to isolate the part of the kidneys that has these tasks, the proximal tubule. Here it can be seen that the level of most B-group vitamins is reduced. It is noticeable here that a low level does not change much, whereas a higher level is more reduced. However, this effect is counteracted by the vitamins, antioxidants and minerals contained in coffee

Caffeine only affects the speed of kidney function, more specifically, it speeds up fluid processing, but it does not significantly affect the amount of fluid.

Liver: blood sugar

In the liver, caffeine is metabolized using the enzyme cytochrome P450. The enzyme CYP1A2 cleaves the original trimethylxanthine into dimethylxanthines and monomethylxanthines. Which in turn have different effects. The breakdown product theobromine, for example, in turn inhibits the breakdown of caffeine itself.

Gastrointestinal: absorption and effects

The absorption time of caffeine is 20min. In the blood circulation it arrived after 30-45min. Soft drinks and tea cause a slower intake of caffeine (more on that later in the text). Once in the blood, caffeine can easily cross the blood-brain barrier, which explains its rapid psychoactive effects. The maximum concentration is reached after about 1-1.5 hours. The effect varies from person to person. At 100kg body weight and a caffeine amount of 100mg, have 1kg body mass 1mg caffeine. At 50kg body weight and a caffeine amount of 100mg, have 1kg body mass 2mg caffeine. Thus, logically different effects arise for different physiological conditions. Furthermore, 68% of coffee drinkers report heartburn after consumption. BRAIN BREW has 70% less acid, which makes this coffee much more compatible and thus counteracts this problem.

Muscles: Power and Contraction

Strength and contract time Endurance and muscle strength are strengthened in two ways. On the one hand, the sodium-potassium pump is activated and, on the other, serotonin is increased. The neuromuscular coordination is also improved. All in all, it is thus possible to respond more quickly to mental demands, for example to unexpected traffic situations.

Differences in activity due to phytochemicals

The biosynthesis of caffeine is different to that in tea or cocoa. This difference leads to significant differences in effect between the various caffeine-containing foods. Even with the same caffeine value can be felt in the one effect, whereas in the other nothing changes. To explain this effect, one has to differentiate two compounds. First, caffeine binding to polyphenols (phytochemicals), such as guarana and tea, is the case. Another substance to be named here is L-Theanine. This has a caffeine opposite effect, so that the invigorating effect of caffeine may even be lost completely. Second, the binding of caffeine to chlorogenic acid, since regular roasting burns most phytochemicals. The binding to this acid leads to a direct release of action. Based on these findings, the unique effect of BRAIN BREW can now be better understood. Due to the longer brewing time of the coldbrew extraction method, a maximum of caffeine is dissolved out. In addition, the beans used are brighter and gentler roasted than average coffee and thus more substances are preserved. Consequently, both said compounds are present, which on the one hand leads to a partly direct effect, on the other hand to a longer-lasting effect (without the attenuation by L-theanine). BRAIN BREW is thus faster, longer lasting and stronger than teas and seeds. The effect of energy drinks has already been shown in various magazines and shown schematically in the graph above, resulting in a less healthy (sugar, chemicals) and short-lasting effect (1 hour). BRAIN BREW customers report effects of between 5 and 8 hours with unique clarity and alertness, with no guilty conscience.

  • Adan A, Prat G, Fabbri M, Sanchet-Turet M (2008) Early effects of caffeinated and decaffeinated coffee on subjective state and gender differences. Progress Neuro-Psychopharmacology Biological Psychiatry 32:1698-1703
  • Anonymous (1890) Action of caffeine. Science 376(15):244
  • Attwood AS, Higgs S, Terry P (2007) Differential responsiveness to caffeine and perceived effects of caffeine in moderate and high regular caffeine consumers. Psychopharmacology 190:469-477

  • Beiglböck W (2016) Koffein: Genussmittel oder Suchtmittel? Springer, Berlin Heidelberg. DOI:10.1007/978-3-662-49564-3
  • Bhupathiraju SN, Pan A, Malik VS, Manson JE, Willett WC, van Dam RM, Hu FB (2013)Caffeinated and caffeine-free beverages and risk of type 2 diabetes. American J Clinical Nutrition 97:163-174
  • Birn H (2006) The kidney and vitamin B12 and folate homeostasis: Characterization of receptors for tubular uptake of vitamins and carrier proteins. American J Renal Physiology 291:F22-36
  • Boekema PJ, Samsom GP, Van Berge Henegouewen GP, Smout AJPM (1999) Coffee and gastrointestinal function: Facts and fiction. Scand J Gastroenterology 230(34):35-39
  • Burke TM, Markwald RR, McHill AW, Chinoy ED, Snider JA, Bessmann SC et al. (2015) Effects of caffeine on the human circadian clock in vivo and in vitro. Science Translational Medicine 7(305) 305ra146
  • Caldeira D, Martins Brandao Alves L, Pereira H, Ferreira JJ, Costa J (2013) Caffeine does not increase the risk of atrial fibrillation. Heart 99(19):1383-1389
  • Cappelletti S, Daria P, Sani G, Aromatario M (2015) Caffeine: Cognitive and Physical performance enhancer or psychoactive drug? Current Neuropharmacology 13:71-88
  • Cheng M, Hu Z, Lu X, Huang J, Gu D (2014) Caffeine intake and atrial fibrillation incidence: Dose-response meta-analysis of prospective cohort studies. Canadian J Cardiol 30(4):448-454
  • Dziallas P (2015) Prüfung der immunmodulatorischen Wirkung von Coffea praeparata und Koffein. Unveröff. Dissertation, Tierärztliche Hochschule Hannover. (Zugriff:08.11.2015)
  • Ferré S (2008) An update on the mechanisms of the psychostimulant effects of caffeine. J Neurochemistry. 105:1067-1079
  • Guessos I, Dobrinas M, Kutlaik Z, Prujim M, Ehret G, Maillard M et al. (2012) Caffeine intake, and CYP1A2 variants associated with high caffeine intake, protect non-smokers from hypertension. Human Mol Genetics Online. DOI:10.1093/hmg/dds137
  • Guessos I, Prujim M, Ponte B, Ackermann D, Ehret G, Ansermot N et al. (2015) Associations of ambulatory blood pressure with urinary caffeine and caffeine metabolite Excretions. Hypertension 65:691-696
  • Hauber W (2002) Adenosin: ein Purinnukleosid mit neuromodulatorischen Wirkungen. Neuroforum 3/02:228-234
  • Heaney RP (2002) Effects of caffeine on bone and the calcium economy. Food Chemical Toxicology 40:1263-1270
  • Heaton K, Griffin R (2015) The effects of caffeine use on driving safety among truck drivers who are habitual caffeine users. Workplace Health Safety 63(8):33-341
  • Huang Z-L, Qu W-M, Eguchi N, Chen J-F, Schwarzschild MA, Fredholm BB et al. (2005) Adenosin A2A, but not A1 receptors mediate the arousal effect of caffeine. Nature neuroscience 8(7). DOI 10.1038/nn1491
  • Hursel R, Westerterp-Plantenga MS (2013) Catechin- and caffeine-rich teas for control of body weight in humans. Am J Clin Nutr 98(6):1682-1693
  • Jinag X, Zhang D, Jinag W (2014) Coffee and caffeine intake and incidence of type 2 diabetes mellitus: a meta-analysis of prospective studies. European J Nutrition 53:25-38
  • Killer SC, Blannin AK, Jeukendrup AE (2014) No evidence of dehydration with moderate daily coffee intake: a counterbalanced cross-over study in a free living population, PLOS ONE 9(1):e8415
  • Klaassen EB, De Groot RHM, Evers EAT, Snel J, Veer ran ECL, Ligtenberg AJM et al (2013) The effect of caffeine on working memory load-related brain activation in middle-aged males. Neuropharmacology 64:160-167
  • Knutti R, Rothweiler H, Schlatter CH (1981) Effect of pregnancy on the pharmacokinetics of caffeine. Eur J Clin Pharmacol 21:121-126
  • Klatsky AI, Hasan AS, Armstrong MA, Udaltsova N, Morton C (2012) Coffee, caffeine and risk of hospitalization for arrhythmias. Permanente J 15(3):19-25
  • Landolt HP (2015) Caffeine, the circadian clock, and sleep. Science 394(6254):1289
  • Lane JD, Lane AJ, Surwit RS, Kuhn CM, Feinglos MN (2012) Pilot study of caffeine abstinence for control of chronic glucose in type 2 diabetes. J Caffeine Research 2(1):45-47
  • Larsson SC, Drca N, Jensen-Urstad M, Wolk A (2015) Coffee consumption is not associated with increased risk of atrial fibrillation: results from two prospective cohorts and a meta-analysis. BMC Med. 13:207. DOI:10.1186/s12916-010447-8
  • Monteiro DR Monteiro MC, Ribeiro-Alves M, Donangelo CM, Trugo LC (2005) Contribution of chlorogenic acids to the iron-reducing activity of coffee beverages. J Agricultural Food Chemistry 53(5):1399-1402
  • Natella F, Scaccini C (2012) Role of coffee in modulation of diabetes risk. Nutr Reviews 70(4):207-217
  • Nieber K (2013) Schwarz und stark – wie Kaffee die Gesundheit fördert. Hirzel, Stuttgart
  • Noguchi K, Matsuzaki T, Sakanashi M, Hamadate N, Uchida T, Kina-Tanada M et al. (2015) Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects. J Pharmacological Sciences 127:217-222
  • Nvalta JW, Fedor EA, Schafer MA, Lyons TS, Tibana RA, Pereira GB, Prestes J (2015) Caffeine affects CD8+ lymphocyte apoptosis and migration in naive and familiar individuals following moderate intensity exercise. Lnt J lmmunopathology Pharmacology. DOI:10.117/03946320g15612795
  • Palatini P (2015) Coffee consumption and risk of type 2 diabetes. Diabetologia 58:199-200
  • Pereira MA, Parker ED, Folsom AR (2006) Coffee consumption and risk of type 2 diabetes mellitus. Arch Internal Medicine 166:1311-1316
  • Pohahka M (2015) Caffeine downregulates antibody production in a mouse model. J Applied Biomedicine 13:1-6
  • Porciuncula LO, Sallabery C, Mioranzza S, Botton PHS, Rosemberg D (2013) The Janus face of caffeine. Neurochemistry International 63:594-609
  • Potera C (2012) Caffeine in wastewater is a tracer for human fecal contamination environ health perspect. 2012 Mar; 120(3):a108-a109. DOI:10.1289/ehp.120-a108a
  • Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL (2001) Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clinical Nutrition 74:694-700
  • Rapuri PB, Gallagher JC, Nawaz Z (2007) Caffeine decreases vitamin D receptor protein expression and 1.25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells. J Steroid Biochemistry Molecular Biology 103:368-371
  • Ribeiro JA, Sebastiao AM (2010) Caffeine and adenosine. J Alzheimer’s Disease 20 (S1):3-15
  • Robertson TM, Clifford MN, Penson S, Chope G, Robertson MD (2015) A single serving of caffeinated coffee impairs postprandial glucose metabolism in over-weight men. British j Nutr. DOl:10.1017/S0007114515002640
  • Roca DJ, Schiller GF, Farb DH (1988) Chronic caffeine or theophylline exposure reduces gamma-aminobutyric acid/benzodiazepine receptor site interactions. Molecular Pharmacology 33(5):481-485
  • Rogers PJ, Heatherley SV, Mullings EL, Smith JE (2013) Faster but not smarter: effects of caffeine withdrawal on alertness and performance. Psychopharmacology 226(2)229-240
  • Senchina DS, Heller JE, Kohut ML, Nguyen NA, Perera MAdN (2014) Alkaloids and athlete immune function: Caffeine, theophylline, gingerol, ephedrine, and their congeners. Exercise Immunology Review 20:68-93; (Zugriff: 08.11.2015)
  • Sharwood LN, Elkington J, Meuleners L, lvers R, Boufous S, Stevenson M (2013) Use of caffeinated substances and risk of crashes in long distance drivers of commercial vehicles: Case-control study. British Medical Journal 346:f1140
  • Shimamoto T, Yamamichi N, Kodashima S, Takahashi Y, Fujishiro M, Oka M et al. (2013) No association of coffee consumption with gastric ulcer, duodenal ulcer, reflux esophagitis, and non-erosive reflux disease: A cross-sectional study of 8,013 healthy subjects in Japan. PLOSONE 8(6)e65996
  • Spaeth AM, Goel N, Dinges DF (2014) Cumulative neurobehavioral and physiological effects of chronic caffeine intake: individual differences and implications for the use of caffeinated energy products. Nutrition reviews 72(s1):34-47
  • Sugiura C, Nishimatsu S, Moriyama T, Ozasa S, Kawada T, Sayama K (2012) Catechins and caffeine inhibit accumulation in mice through the improvement of hepatic lipid metabolism. J Obesity. 155/2012/520510 (Zugriff: 08.1 1 .2015)
  • Tanaka Y, Sakurai M, Goto M, Hayashi S (1990) Effect of xanthine derivatives on hippocampal long-term potentiation. Brain Research 522:63-68
  • Weinberg AW, Bealer BK (2001) The world of caffeine. Routledge, New York
  • Weiß C (2007) Koffein. Ernährungsumschau 4/07:210-215
  • Westerterp-Plantenga MS, Lejeune MPGM, Kovacs EMR (2012) Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obesity Research 13(7):1195-1204
  • Whitehead N, White H (2013) Systematic review of randomised controlled trials of the effects of caffeine or caffeinated drinks on blood glucose concentrations and insulin sensitivity in people with diabetes mellitus. Human Nutr Dietetics 26:111-125
  • Ulvik A, Vollset StE, Hoff G, Ueland PM (2006) Coffee consumption and circulating B-vitamins in healthy middle-aged men and women. Clinical Chemistry 54(9):1489-1496
  • Verhoef P, Jasman WJ, Van Vliet T, Katan MB (2002) Contribution of caffeine to the homocysteine-raising effect of coffee: A randomized controlled trial in humans. Am J Clin Nutrition 76(6):1244-1248
  • Volk BM, Creighton BC (2013) An overview on caffeine. In: Bagchi D, Nair S, Sen ChK (2013) Nutrition and enhanced sports performance. Elsevier, London. 487-495
  • Yu T, Campbell S, Stockmann Ch, Tak C, Schoen K, Clark EAS et al. (2015) Pregnancy-induced changes in the pharmacokinetics of caffeine and its metabolites. J Clin Pharmacology. DOI:10.1002/jcph.632
  • Zaharieva DP, Riddell MC (2013) Caffeine and glucose homeostasis during rest and exercise in diabetes mellitus. Applied Physiol Nutr Metab 38:813-822
  • Zhang Y, Coca A, Casa DJ, Antonio J, Green J M, Bishop PA (2014). Caffeine and diuresis during rest and exercise: A meta-analysis. J Science Medicine in Sport